BIOELECTRONICS PROGRAMME

1. Postdoctoral Fellow - Microfluidics/BioMEMS

The Senior Research Engineer will be involved in a multidisciplinary project covering areas of Microfluidics and Genome sequencing. This project is a joint effort between IME, GIS and SIMTech. He/She will be a part of a team developing microfluidics based solution to DNA sample preparation and pyrosequencing.

Responsibilities:

• Work closely with Biochemists and fellow Engineers to develop lab-on-a-chip device for automated DNA library preparation, emulsion-PCR and sequencer
• Microchip design, fabricate and test the components of the sequencer
• Integrate the microchip with other components and setup the instrument for pyrosequening and collect data
• Prepare the sequencing assay and run it on the device
• Maintaining day-to-day technical documentation on the progress of project
• Prepare progress reports & plans, and attend weekly meetings and present them

Requirements:

• Strong background in developing microfluidic devices for biological and chemical applications
• Basic understanding of Chemistry and Physical behavior of such devices
• Strong hands-on experience, thinking and communication capabilities
• Experience with programming with LabView, Matlab

Candidates must have completed PhD by the time of appointment. Candidates with interdisciplinary background will be given priority. The successful candidate will work closely with other A*STAR institutions - Genome Institute of Singapore (GIS) and Singapore Institute of Manufacturing Technology (SIMTech) with expertise in different areas of this project.

2. Senior Research Engineer - Patch Clamp on Chip

This position involves the development of microfluidic technology for drug discovery. The technology will deliver silicon-based microfluidic chips that can automate the conventional patch clamp method and become a commercial product in pharmaceutical industry for high-throughput screening of drugs against cellular ion channels.

Responsibilities:

The main responsibility will be in the characterization of microfluidic chips in patch-clamp experiments. The candidate may also get involved in other aspects of the project, such as design, simulation, and fabrication of the chips.

Requirements:

• PhD degree in the patch-clamp electrophysiology or related field
• Hands-on skills in the patch-clamp experiments is necessary
• Knowledge of silicon microfabrication, MEMS, and/or microfluidics would be an advantage
• Excellent communication skills and teamwork with strong self-motivation

3. Senior Research Engineer - Microfluidics / Lab On Chip

This position involves the development of a silicon-based microfluidic / Lab-on-chip (LOC) technology for point-of-care diagnostics. The technology will implement a nucleic acid probe assay on an integrated microsystem which can perform nucleic acid purification, nucleic acid amplification via polymerase chain reaction (PCR), and nucleic acid detection, all in an automated fashion.

Responsibilities:

The key responsibilities will be in microfluidic design, integration and characterization of individual components for nucleic acid extraction, PCR amplification, and detection.

Requirements:

• PhD degree in the microfluidics or related field
• Hands-on skills in micro-PCR experiments and characterization
• Understanding of silicon-based microfabrication, MEMS, and /or microfluidics
• Knowledge of LabView and instrumentation
• Excellent communication skills and teamwork with strong self-motivation

4. Senior Research Engineer - Biosensors

This position deals with the development of a silicon-based biosensor technology for point-of-care diagnostics. More specifically, the technology targets a silicon-based nanowire biosensor for electronic detection of charged biomolecules such as nucleic acids and proteins.

Responsibilities:

The key responsibility will include surface functionalization and experimental characterization of biosensors.

Requirements:

• PhD degree in surface chemistry
• Hands-on skills in device functionalization and characterization
• Knowledge of silicon-based microfabrication, MEMS, and/or microfluidics would be an advantage
• Excellent communication skills and teamwork with strong self-motivation

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